Yosef2008

Modify Rankprop to include PPI information (hybrid Rankprop). Accounts for multiple paralogs (mutual Rankprop). Test on netowrk from more than two species.

Comparison also with MRF and ISORank.

Protein form a weighted network where weights are sequence similarity. Initially the query protein is assigned score 1.0 and a diffusion procedure is used to pump the score to the other nodes. Upon termination, each protein is assigned a score, higher score implies greater level of similarity.

Hybrid Rankprop

PPI is also a weighted network, each edge has a confidence score.

Transform weights and normalize them, use a parameter p to determine contribution of PPI vs sequence similarity.

Mutual Rankprop

Consider the top ranked candidates, query from each of them and re-rank them. Uses this to distinguish between the top ranked candidates.