Uncovering the architecture of coordinated gene expression

CREATED: 200810300303 Speaker: Rohan Williams, John Curtin School of Medical Research, Australian National University ** Motivation

• coordinated gene expression
• co-control, co-regulation, co-expression, co-functionality
• gene set approach: find motifs enriched in groups of genes of interest
• shared control approach (this talk) ** Coordinated gene expression from Shared Control
• measure shared control using jaccard co-efficient
• hierarchical clustering based on complete-linkage: 2577 clusters, 2478 non-singletons
• measure of cluster stability using method of Hennig, CSDA 2005
• cluster properties: #genes, tissue specificity, #chromosomes, functional enrichment (P < 0.05) ** Regulatory variation in gene expression
• mapped to quantitative trait loci
• correlation of genetic variation (measure by markers) and gene expression variation
• cis-acting variant (local), trans-acting variant (distinct)
• recent human eQTL studies suggests that cis-variants are far more detectable than trans-variants