True Ancestral Events on Phylogenetic Trees

CREATED: 200702090245 Speaker: Zhao Hao Collaborator: Guillaume Bourque ** Idea

• considering adjacencies that are conserved and unqiue to a partition
• disrupted adjacencies ** relax definition of conserved adjacencies ** refine each edge to find more conserved adjacencies ** Simulations
• average nb of events, r (from 2.5 - 10)
• actual nb of events chosen from [0,2r]
• 7 genomes, 100 genes, random breakage model ** Fragile Breakage model
• x - proportion of weak positions
• y - weak position is y times as likely to be broken ** Camp dataset
• only 14% sensitivity, possibly due to breakpoint reuse, validated experimentally under fragile breakage model ** References
• Ma et al, Genome Res 2006 ** Reconstructing contiguous regions of an ancestral genome