Melvin's digital garden


CREATED: 200905011701 LINK: url:~/Modules/Literature/Sankoff1997.pdf

Partition k genomes into b segments, so as to minimize sum D_i, where D_i is a weighted measure of compactness, density and integrity of segment i

Compactness: max distance in human + max distance in mouse Density: number of genes / metric length Integrity: how many other segments have elements intervening, in one or both species, between members of i

Approach: start with n clusters and iteratively merge them together

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