RielMehan2010
CREATED: 201001261315 LINK: url:~/Modules/Literature/RielMehan2010.pdf Title: An integrative modular approach to systemically predict gene-phenotype associations
** Challenges in microarray expression
- normalization
- multiple platforms
- outliers
** Network based integration
- co-expression network per microarray
- find recurrent dense subgraphs in multiple co-expression graphs
- want co-expression clusters that are enriched for specific functions/conditions
- map dataset to phenotype term using unified medical language
** Algorithm
- based on simulated annealing to find subset of vertices that are
- large
- dense
- phenotype specific (hypergeometric p-value)
Use overrepresentation of GO terms to validate gene sets = power of gene sets for annotation