Phenotype-Genotype networks

CREATED: 200910031457 ** Phenotype network

• nodes are diseases
• text mining from OMIM database
• 4146 phenotype and 29489 edges

** PPI network

• HRPD database: 8919 proteins, 34364 PPIs

• HRPD, OPHID BIND MINT database: 14433 proteins, 72431 PPIs

• Phenotype-gene associations

• Do graph partitioning using spectral framework to find disease module

• Do linear regression