Lipidomics
CREATED: 200612290616 Related: http://www.lipidprofiles.com/main.htm
** Metabolics
lipidomics
head group
tails
sugars
toxins
** Uses
energy store (metabolism)
cellular membranes
foreign lipids - diseases caused by bacteria
signaling
** Interactions
lipid receptors
interfacial bindings
integral interactions
with proteins
** Equipment
ESI-MS
Tandem MS
Precursor Ion Scan (class specific fragmentation)
Thin layer chromatography
** Examples
growing vs dormant bacteria
difference in lipids
look at lipid profile of different states, overlay difference profile
identification of ions in difference profile
identification of biochemical pathway
** Analysis of lipid profile
Correlation Optimized Warping algorithm
alignment of profile to eliminate warping
Identification of the peaks
Similarity of lipids (molecular mimicry)
** Application of lipidomics