Lasch2004

CREATED: 200906170312 LINK: url:~/Modules/Literature/Lasch2004.pdf Considered Ward’s algorithm, Fuzzy C-means and k-means algorithm for colorectal adenocarcinoma.

In preprocessing the data, the following quality tests were applied

• 50-250 integral intensity criterion in the wavelength range 950-1750cm^-1.
• SNR test with 500 as threshold (signal: maximum of amide I band, noise:
• standard deviation in the spectral range 1800-1900cm^-1).

Spectra passing the tests were converted to first derivative using a nine-smoothing point Savitzky-Golay algorithm. Derivative spectra were scaled such that the sum deviation over 950-1750cm^-1 equals unity (vector normalization).