Melvin's digital garden

Genomic Data Assimilation for Discovering New Knowledge Regarding Biological Pathways

CREATED: 200809290400 Speaker: Rui Yamaguchi

  • Types of networks: signalling networks, gene regulatory networks, metabolic networks
  • Integrate biological models and biological data to discover new knowledge
  • Data assimilation is statistical framwork to integrate simulation model and data
  • Formulated as a non-linear state space model
  • For sparse data, model tend to overfit, hence need to have trade-off between goodness of fit and penalty for parameter estimation
  • Results on EGFR pathway

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