Genomic Data Assimilation for Discovering New Knowledge Regarding Biological Pathways

CREATED: 200809290400 Speaker: Rui Yamaguchi

• Types of networks: signalling networks, gene regulatory networks, metabolic networks
• Integrate biological models and biological data to discover new knowledge
• Data assimilation is statistical framwork to integrate simulation model and data
• Formulated as a non-linear state space model
• For sparse data, model tend to overfit, hence need to have trade-off between goodness of fit and penalty for parameter estimation
• Results on EGFR pathway