Melvin's digital garden

Genome island boundary refinement

speaker: Wang Mengge event: RAS group meeting

Given rough GI region from window based method, compute a more accurate GI boundary

Possible approaches:

  • structural features of GI
    • genes should not be cut apart
    • direct repeat on boundary
    • tDNA gene split apart by insert
  • based on probability
    • HMM: native vs GI
    • MJSD used in finding recursive segmentation position on boundary

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