Evolution of regulatory modules

CREATED: 200810140719 Speaker: Aviv Regev ** Comparing S. cerevisiae and S. pombe

• Regulatory modules: group of co-expressed, co-regulated genes
• Conserved transcription modules in E. Coli and Human
• Adaptation of regulatory modules in S. cerevisiae and S. pombe?
• Find modules using bi clustering, comparing modules between two species -> orthologous modules
• Look at tf binding sites of the modules ** Include more species and putative modules
• construct a phylogenetic profile of binding sites
• parsimonious reconstruction of ancestral binding sites
• eg, from Homol-D to RAP1 ** Evolution of regulatory modules
• cis-buffering in modules
• how do novel sites emerge and invade many genes
• neutral drift
• selective advantage to redundancy
• undefined selective role ** Reconstructing orthogroups ** Phylogeny of modules