Evolution of duplicates in Yeast

CREATED: 200810200337 Speaker: Olga Troyenskaya

• 2 mechanisms of gene duplication ** single gene (generation -> fixation -> preservation) ** whole genome duplication (WGD -> rearrangements/gain/loss -> preservation)
• Functional difference between WGD and small scale duplications ** relation between duplicate similarity and essentiality? ** relation between duplicate sequence divergence and expression divergence?
• Quantification of functional divergence using Bayesian network to integrate (bioPIXIE), train using GO data
• Functional enrichment of SSD and WDG are different
• Use shared functional relationship as similarity in function, WGD > SSD for sequence identity vs %functional/physical interaction partners
• WGD much more functional similar as compared to SSD
• SSD more similar in expression