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CREATED: 201001261613 Title: Discovering biomolecular mechanisms with computational biology

Fundamental problem in life sciences large number of functionally uncharacteried genes, yet to be discovered functions/structures/pathways

Biomolecular function discovery ANNIE - wet lab - sequence analysis

Proteins consists of globular and non-globular domains.

Globular domains: significant sequence similarity, annotation transfer from homologous groups of proteins

Non-globular domains: repetitive patterns

Protein sequence analysis

mask out non globular regions

determine occurrence of known domains

search distant homologs for remaining segments

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