CREATED: 201001261613 Title: Discovering biomolecular mechanisms with computational biology
Fundamental problem in life sciences large number of functionally uncharacteried genes, yet to be discovered functions/structures/pathways
Biomolecular function discovery ANNIE - wet lab - sequence analysis
Proteins consists of globular and non-globular domains.
Globular domains: significant sequence similarity, annotation transfer from homologous groups of proteins
Non-globular domains: repetitive patterns
Protein sequence analysis