Durand2003b

[file:///home/melvin/Modules/Literature/Durand2003b.pdf]

Vertebrate evolution: doubling and shuffling with a full deck

Challenges: small, noisy datasets, lack of computational accuracy and statistical rigor

Ken Wolfe et al. presented a genome-scale, statistically rigorous analysis of evidence base on spatial organization of duplicated genes and estimates of duplication times.

[McLysaht2002] is based on a comprehensive spatial and temporal approach. Monte Carlo significance testing to validate spatial results, two different methods to estimate gene duplication times.

Testable predictions of the 2R hypothesis are based on spatial or temporal evidence.

However, conserved synteny between paralogous genes does not constitute rigorous proof of polyploidization without statistical analysis.

Temporal predictions are based on estimates of gene duplication times and gene family topologies. Estimated gene duplication times should show two distinct waves early in the vertebrate lineage. Assumes a constant molecular clock.