Drug pathway decipherer

CREATED: 200808140306 Speaker: Wong Limsoon ** Problem Given expression data for drug responders and non-responders, determine action pathway of the drug. ** Key idea *Find chains in pathways that are active in responders but disrupted in non-responders. *Assume gene expressions of action pathway is consistent among responders ** Workflow #Extract chain from known pathway #Is the chain unbroken in reponders and broken in non-responders? #Is the state of this chain consistent in all responders? #Candidate drug action pathway