System Biology

CREATED: 200701150145 ** Modelling biological processes

• qualitative
• quantitative ** predict actions of metabolites in a limited scope ** using petri net, differential equations ** eg. WNT signalling pathway

** Rule based systems

• Brutlag et al
• difficult to obtain parameters of DE
• qualitative can explain conclusion/inference

** Simulation of DNA metabolism

• polymerase I, nick translation, strand displacement -> template matching
• only for single ploymerase enzyme
• limited to pathways without cycles
• probability of different scenarios not available